Fig. 6.

Co-registered images showing distribution of ¹²³I-albumin into the Sylvian fissure after convection-enhanced delivery from a catheter with proximal ports: outline (A) and magnified view (B) of single-photon emission computed tomography image of ¹²³I-albumin distribution (blue) shown co-registered with axial MR image (patient 18). The tumor is outlined in red. A second catheter trajectory is shown in yellow at the bottom of A. The most proximal port on this catheter is located 17.0 mm from the tip. In this instance, the infusate appears to have exited the catheter through the most proximal port, which was communicating with the subarachnoid cerebrospinal fluid (CSF) space within the deep portion of the Sylvian fissure between the frontal and temporal lobes of the brain. This allowed the infusate to leak completely into the CSF spaces without any penetration of the parenchyma.