Table 3.

Dose-limiting toxicities

Dose Level	No. Patients	Grade 3 or 4 Hematologic Toxicity	Grade 4 Nonhematologic Toxicity	Increased ICP	Decrease in GCS or New Focal Neurologic Deficit	Percent DLT
Residual tumor
25 ng/ml	3	0	0	0	0	0%
50 ng/ml	6	0	0	0	1a	16.7%
100 ng/ml	6	0	1b	0	0	16.7%
No residual tumor
25 ng/ml	3	0	0	0	0	0%
50 ng/ml	2	0	0	0	0	0%
100 ng/ml	0	0	0	0	0	0%

Abbreviations: ICP, intracranial pressure; GCS, Glasgow Coma Scale score; DLT, dose-limiting toxicity.

^aHemiparesis that may have been related to recurrent tumor.

^bConstitutional.