Fig. 5.

Comparison of positioning between autoimmune TCRs and nonautoimmune TCR. HA1.7/HA306–318/DR1 indicates the positioning of a nonautoimmune TCR. All of the others are autoimmune TCRs. Black lines are drawn between the S–S bonds of TCRα and TCRβ. Coloring is the same as in Fig. 4C. N, N-terminal shift; R, counterclockwise rotation. The degrees of rotation taking TCR-HA1.7 on HA306–318/HLA-DR1 as 0° were as follows: TCR-3A6, −7°; TCR-172.10, −4°; TCR-Ob.1A12, +37°; Ob.2F3, +47°; and TCR-Ob.3D1, +48°.