FIG. 3.

Effects of PFOA and PFDA on mRNA expression of Oatp1a1, 1a4, and 1b2, as well as Ntcp in mouse livers. Adult male C57BL/6 WT mice (n = 5 per treatment) were given a single i.p. administration of control (propylene glycol:water; vol/vol, 1:1), PFOA (40 mg/kg), or PFDA (80 mg/kg). Two days later, mouse livers were collected. Total RNA from mouse livers (n = 5 per treatment) was analyzed by the bDNA assay for the mRNA expression of each transporter. The data are reported as RLUs per 10 μg of total RNA, and are presented as mean ± SEM. Asterisks indicate statistically significant differences between control and PFOA or PFDA-treated male mice (p < 0.05).