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. 2008 Jul 22;106(1):29–36. doi: 10.1093/toxsci/kfn147

FIG. 8.

FIG. 8.

Effects of PFDA on Cyp2B protein expression in WT and FXR-null mouse livers. The black and the dark-latticed bars represent regulation of Cyp2B protein by vehicle treatment; the striated bars depict regulation of Cyp2B protein by PFDA treatment. Adult C57BL/6 WT or FXR-null male mice were given a single i.p. administration with the vehicle, propyleneglycerol:water (1:1, vol/vol) or PFDA at dose 50 mg/kg of body weight. Mouse livers were collected after two days. Microsomal protein from control or PFDA-treated mouse livers (n = 3/treatment) was analyzed by Western blots for the protein expression of Cyp2B. (a) Protein levels of Cyp2B in mouse liver microsomes were analyzed by Western blotting. (b) Protein levels of Cyp2B in mouse liver microsomes are expressed as ratio of Cyp2B to β-actin protein levels per 75 μg microsomal protein. Data are presented as mean ± SEM. Asterisks indicate statistically significant differences between control and PFDA-treated male mice (p < 0.05).