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Figure 1 The fibrillin‐1 gene FBN1 spans about 235 kb of genomic DNA on chromosome 15q21.1, and has a transcript size of 9749 nucleotides; the coding sequence of FBN1 is spread over 65 exons,21 and three alternatively spliced non‐coding 5′ exons have been described.249 With several exceptions, single exons code for the domains in fibrillin‐1 as shown here.
