Table 4 Odds ratio for coronary heart disease by mutation type in men and women combined, unadjusted and adjusted for risk factors.
| CHD+ve/CHD−ve (% CHD+ve) | OR* (95% CI) | OR† (95% CI) | OR‡ (95% CI) | OR§ (95% CI) | |
|---|---|---|---|---|---|
| None | 55/101 (35.2) | 1.00 | 1.00 | 1.00 | 1.00 |
| LDLR (any) | 91/145 (38.6) | 1.84 (1.10 to 3.06) p = 0.02 | 1.81 (1.08 to 3.01) p = 0.02 | 2.23 (1.30 to 3.83) p = 0.004 | 1.70 (1.01 to 2.86) p = 0.05 |
| APOB (R3500Q) | 6/4 (60) | 3.40 (0.71 to 16.36) p = 0.13 | 3.44 (0.71 to 16.8) p = 0.13 | 4.06 (0.84 to19.68) p = 0.08 | 3.76 (0.76 to 18.76) p = 0.11 |
| PCSK9 (D374Y) | 6/1 (85.7) | 19.96 (1.88 to 211.55) p = 0.01 | 16.22 (1.56 to 168.3) p = 0.02 | 47.73 (3.79 to 601) p = 0.003 | 14.74 (1.35 to 161) p = 0.03 |
| p Value | p = 0.03¶ | p = 0.003 | p = 0.006 | p = 0.001 | p = 0.01 |
*Model 1 adjusted for age, sex, smoking (never v ex and current) and systolic blood pressure at recruitment.
†Model 2 plus HDL at recruitment.
‡Model 3 plus LDL at recruitment.
δModel 1 plus recorded pretreatment. Total cholesterol or group average value if data not recorded.
¶Fisher exact test.