Fig. 2.

Differential action of LC and derivatives on recombinant large conductance, calcium- and voltage-gated potassium (BK) (cbv1+β₁) channels in inside-out (I/O) patches excised from Xenopus laevis oocytes. A: Representative single-channel records obtained at Vm = −20 mV in symmetric Ca²⁺ = 10 μM. Arrows indicate baseline. Each compound (150 μM) and vehicle was tested on the same patch; each compound-vehicle pair was tested on different patches excised from different oocytes. B: Averaged channel responses to LC and derivatives. * P < 0.05; ** P < 0.01 vs. vehicle; n = 6 (LC), n = 6 (epialloLC), n = 4 (epiLC), n = 3 (alloLC), and n = 4 (5-cholenic acid-3β-ol).