Figure 2 Pedigrees of families 1 and 2, showing haplotypes for chromosome 10q23 microsatellite markers. Asterisks denote individuals in family 1 who were genotyped by the high throughput SNP array. Closed, grey, and open symbols denote affected, unknown, and unaffected individuals, respectively. Boxed haplotype denotes the putative disease haplotype. The letter “r” besides the allele refers to recombination. Haplotypes for individuals 1 and 3 from family 1 and individual 1 from family 2 were inferred.