Figure 4 Mutation in BMPR1A causes HMPS. (A) The list of SNPs, microsatellite (MS) markers, and characterised genes in the critical interval of 83–90 Mb on 10q23. Genes in bold are genes with OMIM identification. (B) Sequence analysis showing BMPR1A 11 bp deletion at codon 43. (C) All affected individuals (asterisks) of family 2 show both homoduplex and heteroduplex bands of the amplified 240 and 229 bp fragments while all unaffected individuals exhibit the 240 bp homoduplex bands only when run on a 8% polyacrylamide gel.