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. 1998 Dec;9(12):3351–3365. doi: 10.1091/mbc.9.12.3351

Figure 8.

Figure 8

Functional domains in dynein ICs. The IC140 is shown diagramatically in comparison to other dynein ICs. The shaded boxes indicate WD repeats; the double loops indicate predicted coiled-coil regions, and the asterisks denote WD repeats that have been implicated in subunit interactions (redrawn following Yang and Sale, 1998). IC78 is the outer arm IC that has been implicated in binding to the axoneme (see MT regions indicated, King et al., 1995). IC69 is another IC required for outer arm assembly (Mitchell and Kang, 1991). Mutations in the N-terminal region can alter flagellar beat frequency (see BF, Mitchell and Kang, 1993). IC2C (IC74) is a cytoplasmic dynein IC that appears to mediate interaction with the p150glued subunit of the dynactin complex (see p150, Vaughan and Vallee, 1995; Steffen et al., 1997).