Table 1.
Interaction of antibiotics with coatomer
| Compund | Precipitates coatomera | Inhibits precipitation by neomycinb |
|---|---|---|
| Neomycin | Yes (0.05) | |
| Neamine | Yes (0.7) | |
| Paromomycin | Yes (0.7) | |
| Kanamycin B | Yes (0.4) | |
| Sisomycin | Yes (0.3) | |
| 2-Deoxystreptamine | No | Yes (8.0) |
| Geneticin (G418) | No | Yes (2.0) |
| Gentamycin C1 | No | Yes (0.5) |
| Kanamycin A | No | Yes (2.0) |
| Hygromycin B | No | Yes (5.0) |
| Lividomycin | No | Yes (1.0) |
a
Precipitation was measured as in Figure 1. Values in parenthesis are the approximate concentrations (mM) to precipitate 50% of the coatomer.
b
Inhibition of coatomer precipitation by neomycin was measured as in Figure 5. Values in parenthesis are the approximate concentrations (mM) to inhibit precipitation by 50%.