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. Author manuscript; available in PMC: 2008 Oct 8.
Published in final edited form as: J Med Chem. 2005 Sep 8;48(18):5738–5748. doi: 10.1021/jm050352m

Table 4.

Δ(ΔG°) variations caused by structural changes of the sn-2 carbonyl in DAG-lactones in the presence or absence of phosphatidyl serine (PS).

+PS −PS
Kd(B)/Kd(A) Δ(ΔG°) kcal/mol Kd(B)/Kd(A) Δ(ΔG°) kcal/mol
↓ Kd(CO)/KdCO) 0 → Kd(CO)/Kd(CO) 2.82
↓ Kd(CS)/KdCO) 0.74 → Kd(CS)/Kd(CS) 2.38
↓ Kd(CH2)/KdCO) 3.26 → Kd(CH2)/Kd(CH2) 2.03