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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Dev Cell. 2008 Sep;15(3):359–370. doi: 10.1016/j.devcel.2008.06.015

Fig. 6. Histologic analysis of Ifn-PrP mice reveals mild neurodegeneration.

Fig. 6

(A-D) H&E stained saggital brain sections show no alterations to gross brain morphology or development in Ifn-PrP or Opn-PrP mice at either ∼2 months or ∼2 years of age. Green boxes indicate regions shown in greater detail in panels B-D.

(E) Immunostaining for calbindin to visualize Purkinje cells (brown). Note that neither the Purkinje cells, granular layer (left) or molecular layer (right) are affected grossly in Ifn-PrP mice.

(F) GFAP staining of Ifn-PrP or Opn-PrP mice at either ∼2 months or ∼2 years of age. Shown is a region of hippocampus where age-dependent increase in reactive astrocytes is observed in Ifn-PrP mice beyond that seen in old Opn-PrP mice.

(G) Fluoro-Jade C staining of Ifn-PrP or Opn-PrP mice at ∼2 years of age. Shown are regions where increased staining is observed in Ifn-PrP mice. Note that no staining was observed in young mice of either genotype (data not shown).

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