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. 1999 Nov;10(11):3583–3594. doi: 10.1091/mbc.10.11.3583

Figure 1.

Figure 1

Site-directed mutations introduced in the ATPase motif II and the acidic region of CSB. The CSB protein contains the ATPase and helicase motifs conserved in superfamily 2 as well as a negatively charged domain in which 22 of 39 residues are acidic (56%). The E646Q mutation in CSB changes the highly conserved glutamic acid in ATPase motif II to glutamine (CSBE646Q). The ACMUT1 mu-tation replaces acidic residues at positions 381, 382, 384, and 385 with alanines (CSBACMUT1). The AC377 mutation deletes 10 consecutive acidic residues (378–387) from the CSB protein (CSBAC377).