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. Author manuscript; available in PMC: 2008 Oct 8.
Published in final edited form as: Br J Nutr. 2008 Aug;100(2):278–282. doi: 10.1017/S0007114507894438

Figure 1.

Figure 1

(A) Structure of the PPARα gene (www.ensembl.org, gene identity number ENSRNOG00000021463). The location of the CpG island was identified using Methprimer (www.urogene.org/methprimer). (B) Nucleotide sequence of the CpG island showing individual CpG dinucleotides and putative transcription factor binding sites. (C) and (D). Methylation of individual CpG dinucleotides in the PPARα promoter in the liver of the offspring of rats fed either a Control, protein restricted (PR) or PR with increased folic acid content (PRF) diet during pregnancy. Data are expressed as mean (SD). (C) d34 male and female offspring (n 5 / group), *indicates values significantly different (P < 0.05) from the Control group by 1-way ANOVA with Dunnett's post hoc test. (D) d80 male offspring (n 5 / group), *indicates values significantly different (P < 0.05) from Control by Student's unpaired t-test. AHR, aryl hydrocarbon receptor; CPBP, Core promoter-binding protein; CREB, cAMP responsive element binding protein; EGRF, Wilms tumour factor; HESF, hey like transcriptional repressor; NAZ, Myc associated zinc finger protein; NRF1, Nuclear respiratory factor 1; SP1, specificity protein 1; WHNF winged helix protein; ZF5F zinc finger domain transcription factor.