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(a) Variations in Hb desaturation as a function of the off rate(k, s−1) when Bi = 10. The Hb has the properties p50 = 15 mmHg, n = 3, DHbO2 = 1 × 10−6 cm2/s, and [Hb] = 10 g/dl. (b) Effect of varied O2 binding cooperativity on O2 transport for generic Hb with p50 = 5 mmHg and p50 = 35 mmHg (DHbO2 = 3 × 10−7 cm2/s, [Hb] = 10 g/dl Hb) with Bi = 10. Cooperativity increases O2 delivery for high p50 Hbs and decrease O2 delivery for low p50 Hbs.
