Table 1 Timing of vaginal opening (VO).

Strain	n (litters)	Age at VO (days) (mean±SD)	p v WT for VO	Body weight (g) at VO (mean±SD)	p v WT for body weight
WT	26 (18)	31.3±1.4	NA	15.7±1.4	NA
			Corrected*		Corrected*
			p v B6 (VO)		p v B6 (body weight)
S489X−/S489X−	14 (11)	48.9±9.3	<0.00001	13.9±1.5	0.0003
S489X−/S489X+	21 (12)	27.6±2.2	<0.00001	14.5±1.8	NS
ΔF508−/ΔF508−	10 (7)	47.9±14.7	<0.00001	12.9±2.1	0.0002
ΔF508−/ΔF508+	14 (8)	27.1±2.5	<0.00001	14.7±2.0	NS

*For the analysis of the timing of VO and body weight at VO in each strain versus homozygous non‐mutant Cftr (WT) mice, statistical significance was attributed to p<0.0125 to correct for multiple hypothesis testing; see Methods for details.

n, number of animals; NA, not applicable; NS, not significant; SD, standard deviation; VO, vaginal opening.