Table 3 Overrepresentation of heterogeneous disease genes in HPRD protein interaction set (χ2test).
| Number of proteins in interaction set | Subset also in disease protein set | Subset also in disease protein set (percentage) | χ2 Test | p Value | |
|---|---|---|---|---|---|
| HPRD set (literature based) | 6005 | 678 | 11.29% | 550.2098 | <2.2e‐16 |
| Human Y2H set (high throughput) | 2686 | 146 | 5.44% | 4.845 | 0.03 |
| Fly set (high throughput) | 4706 | 276 | 5.86% | 18.109 | 2.1e‐5 |
| Worm set (high throughput) | 1933 | 101 | 5.23% | 2.086 | 0.15 |
| Yeast set (high throughput) | 2455 | 141 | 5.74% | 7.838 | 0.005 |
| Reference set – all human protein coding genes in Ensembl | |||||
| Total | In disease set | Percentage | |||
| Ensembl known genes | 22242 | 1003 | 4.51% | ||
The disease gene enrichment in HPRD is highly significantly higher than in the high throughput sets (p<1e‐13 after Bonferroni correction for every case).