Figure 2. Reduced body weight and fast-twitch muscle mass in Myoz1-deficient mice.
(A) Significant reduction in body weight of Myoz1 KO mice (n = 13–15) and (B) in body weight normalized to tibia length in Myoz1 KO mice (n = 6). (C) Morphology of skinned hindlimbs of Myoz1 KO mouse, revealing a slimmer shape of the calf in Myoz1 KO mice compared with WT littermate. Original magnification, ×4. (D) Weight of gastrocnemius in Myoz1 KO mice compared with WT littermates (n = 13–15). (E) Gastrocnemius mass normalized to tibia length (n = 6). (F) Weight of soleus in Myoz1 KO mice compared with WT controls. (G) Soleus weight normalized to tibia length. *P < 0.05, †P < 0.01, ‡P < 0.001.