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. 2008 Oct 9;118(11):3598–3608. doi: 10.1172/JCI36277

Figure 8. Enhanced regeneration in Myoz1 KO mice after cardiotoxin injury.

Figure 8

Calsarcin-2–deficient mice and WT controls were subjected to unilateral cardiotoxin injection into the tibialis anterior. (A) After 4 days, Myoz1 KO muscles showed enhanced formation of new muscles fibers, as well as an increase in cell proliferation as measured by BrdU incorporation (B and C). After 6 days, this effect could still be observed (D). (E) Weight loss of tibialis anterior muscle was attenuated in Myoz1 KO compared with WT mice. Myoz1 KO mice showed a higher cell surface area recovery (F) and a decreased area of degenerated tissue (G) compared with WT mice. *P < 0.05, P < 0.001. Scale bars: 10 μm.

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