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Low- (A, C, E) and high-power (B, D, F) photomicrographs of sections through the mid-SN from age-matched control (A, B), H&Y stage3 PD (C, D), and H&Y stage5 PD (E, F), illustrating the decline of Nurr1-ir intensity (arrows) in H&Y stage3 PD (C, D) and the severe decrease of Nurr1-ir neuronal number in H&Y stage5 PD (E, F). Scale bar in D= 300μm (applies to A, C, E), 20μm in B, D, F. Arrows in A indicate dorsal (D), ventral (V), median (M), and lateral (L) orientation.
