Figure 1 Survivin expression in rhabdomyosarcoma. (A) Representative immunohistochemical analysis of Survivin expression in a rhabdomyosarcoma tumour from a tissue microarray. Nuclear Survivin reactivity is strong in both alveolar and ERMS tumours, whereas no nuclear Survivin staining is observed in normal muscle tissue. (B) Transcriptional analysis of Survivin and the Survivin splice variants in representative cell lines of embryonal (ERMS; RD2) and alveolar (ARMS; CW9019, RH28, RH30) rhabdomyosarcoma compared to normal muscle RNA. Survivin and splice variants are expressed at high levels in all rhabdomyosarcoma cell lines compared to normal muscle controls.