Table 5 Haplotype frequencies and tests of association for haplotypes defined by the MTHFR gene variants 677C→T and 1298A→C.
| Haplotype | Estimated haplotype frequency | Observed | Expected | Var(O−E) | χ2(1 df) | p Value* | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 677C‐1298A | 41.6% | 333.54 | 312.72 | 74.87 | 5.79 | 0.0159 | ||||||
| 677C‐1298C | 27.7% | 183.78 | 208.32 | 62.90 | 9.57 | 0.0020 | ||||||
| 677T‐1298A | 30.4% | 233.32 | 228.32 | 68.85 | 0.36 | 0.5365 | ||||||
| 677T‐1298C | 0.4% | 1.35 | 2.64 | 0.98 | 1.69 | 0.1947 |
Global χ2 test on 3 degrees of freedom = 12.17, p = 0.0079.
*Significant probabilities derived from the haplotype based TDT (TRANSMIT) based on 10 000 bootstrap samples and robust standard errors.
E, expected; MTHFR, methylenetetrahydrofolate reductase; O, observed; Var, variance.