Figure 1.
Integration of publicly available resources as a foundation for InnateDB. More than 100 000 interactions were integrated into InnateDB from the Molecular Interaction (MINT) database (Chatr-aryamontri et al, 2007); the IntAct database (Kerrien et al, 2007); the Database of Interacting Proteins (DIP) (Salwinski et al, 2004); the General Repository for Interaction Datasets (BioGRID) (Breitkreutz et al, 2007) and the Biomolecular Interaction Network Database (BIND) (Alfarano et al, 2005). Cross-references to more than 2500 pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database (Kanehisa et al, 2007), the NCI-Nature Pathway Interaction Database (PID) (http://pid.nci.nih.gov), Integrating Network Objects with Hierarchies (INOH) pathway database (http://www.inoh.org/), NetPath (http://www.netpath.org) and the Reactome database (Joshi-Tope et al, 2005) were also incorporated. Up-to-date versions of Ensembl (www.ensembl.org) provide details of human and mouse genes, transcripts and proteins along with rich protein and gene annotation from the Universal Protein Resource (UniProt) (The UniProt Consortium, 2007), Gene Ontology (Ashburner et al, 2000) and Entrez Gene (http://www.ncbi.nlm.nih.gov/).