Figure 3. Serum levels of soluble von Willebrand Factor (vWF) (A), P-selectin (B), vascular cell adhesion molecule 1 (VCAM-1) (C), intercellular adhesion molecule-1 (ICAM-1) (D) and platelet endothelial cell adhesion molecule-1 (PECAM-1) (E) in healthy donors (HD), patients with systemic sclerosis (SSc) without pulmonary arterial hypertension and patients with SSc with pulmonary arterial hypertension (SSc-PAH) at baseline (t 0) and after 12 months (t 12) of bosentan therapy. Values are mean SD).