Table 5. Quantitation of immunoreactivities in colonic biopsies from IBS and controls.

	n	TRPV1	SP	PGP9.5	c-kit	CD3	CD4
IBS	23	3.2 (2.2–5.1)	2.3 (0.7–3.1)	5.0 (3.2–6.1)	4.0 (2.9–5.6)	8.7 (5.9–12.1)	1.0 (0.5–3.8)
Control	22	0.9 (0.5–2.1)	0.8 (0.5–1.5)	2.7 (1.7–3.8)	2.9 (1.9–3.9)	5.4 (3.9–7.9)	1.0 (0.3–1.8)
Ratio of medians IBS:control	–	3.56	2.96	1.86	1.36	1.60	0.98
p Value	–	<0.0001	0.01	0.002	0.02	0.03	0.29

Values are medians with interquartile range in parentheses. TRPV1 is expressed as fibres/mm², and the other immunoreactivities as percentage area. Significance of differences between IBS and controls was determined by Mann–Whitney U test.

IBS, irritable bowel syndrome; PGP, protein gene product; SP, substance P; TRPV1, transient receptor potential vanilloid type-1.