Table 1. The percentage and number of insertions in various regions of HCV.

Region	Genome Location	Size (nucleotides)	Total Insertions in a Region	Tolerated	Attenuated	Lethal
5′NTR	55–340	286	93 (3.9%)	37 (39.8%)	8 (8.6%)	48 (51.6%)
Core	341–913	573	81 (3.4%)	24 (29.6%)	8 (9.9%)	49 (60.6%)
E1	914–1489	576	109 (4.5%)	6 (5.5%)	0 (0.0%)	103 (94.5%)
E2	1490–2590	1101	272 (11.3%)	24 (8.8%)	8 (3.0%)	240 (88.2%)
p7	2591–2779	189	64 (2.7%)	18 (28.1%)	2 (3.1%)	44 (68.8%)
NS2	2780–3430	651	199 (8.3%)	15 (7.5%)	3 (1.5%)	181 (91.0%)
NS3	3431–5323	1893	467 (19.5%)	39 (8.4%)	5 (1.0%)	423 (90.6%)
NS4A	5324–5485	162	26 (1.0%)	3 (11.5%)	1 (3.9%)	22 (84.6%)
NS4B	5486–6268	783	177 (7.4%)	23 (13.0%)	0 (0.0%)	154 (87.0%)
5A Region 1	6269–7016	748	170 (7.1%)	21 (12.4%)	8 (4.7%)	141 (82.9%)
5A Region 2	7017–7318	302	82 (3.4%)	12 (14.6%)	18 (21.0%)	52 (63.4%)
5A Region 3	7319–7666	348	106 (4.4%)	48 (45.3%)	16 (15.1%)	42 (39.6%)
NS5B	7667–9442	1776	467 (19.5%)	92 (19.7%)	22 (4.7%)	353 (75.6%)
3′NTR	9443–9571	129	86 (3.6%)	12 (13.95%)	12 (13.95%)	62 (72.1%)
Total	55–9571	9517	2399 (100.0%)	374 (15.6%)	111 (4.6%)	1914 (79.8%)