Superposition of alkaline phosphatase superfamily members showing geometrically conserved structural core. AlkP family members shown as ribbons, 1ALK (alkaline phosphatase: red) [105],1EJJ (phosphoglycerate mutase: green) [106], 1AUK (arylsulfatase: blue) [107], 1FSU (arylsulfatase: magenta) [108], 2GSN (Xac. NPP: yellow) [109], available in the Protein Databank [104].