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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: J Vasc Surg. 2008 Jul 15;48(3):519–526. doi: 10.1016/j.jvs.2008.03.064

Figure 5. Effect of doxycycline therapy on the circulating levels of MMP-9.

Figure 5

The mean levels of plasma MMP-9 are plotted before and at all follow-up intervals after placement of an aortic endograft. While the surgical procedure caused an initial increase in plasma MMP-9, these levels decreased over the first post-operative month in both groups. While plasma MMP-9 subsequently increased by 6 months in the placebo treated patients, doxycycline treatment resulted in a continued decrease of circulating MMP-9 in this interval. At 6 months plasma MMP-9 decreased significantly below pre-operative levels in the doxycycline treated group (P<.03), but not in the placebo treated patients. The overall change in MMP-9 during the study was significantly different between treatment groups (P<.009)