Table 3. LOD scores >1.5 and p values of multipoint linkage analysis for muscle and bone cross-sectional area (MBA) and knee strength phenotypes .
Trait | SNP | Location | cM | LOD unadjusted | pValue | Empirical p value | LOD covariate MBA | LOD covariate MBA + Sport index |
>1.5 LOD regions for unadjusted phenotypes (and comparison after covariation) | ||||||||
MBA mid thigh | rs695167 | 8q13.2 | 79.78 | 1.719 | 0.002 | 0.016 | — | 1.254* |
rs296736 | 12q13.13 | 63.82 | 1.783 | 0.002 | 0.012 | — | 1.712* | |
rs926949 | 14q32.2 | 109.13 | 2.998 | 0.0001 | 0.0049 | — | 2.854* | |
rs7175643 | 15q32.2 | 99.82 | 2.048 | 0.0011 | 0.0102 | — | 1.078* | |
Torque at 30° flexion | rs1445128 | 2p24.2 | 41.12 | 2.572 | 0.0003 | 0.0097 | 1.532 | 1.615 |
rs246079 | 12q24.11 | 124.26 | 1.791 | 0.002 | 0.018 | 0.335 | 0.463 | |
Torque–length flexion | rs7846911 | 9q21.32 | 81.01 | 2.004 | 0.0012 | 0.0003 | 2.858 | 2.824 |
rs4962424 | 10q26.13 | 153.12 | 1.81 | 0.002 | 0.003 | 2.524 | 2.524 | |
rs225553 | 12q24.32 | 147.91 | 1.615 | 0.003 | <0.001 | 1.261 | 1.259 | |
rs760267 | 14q24.3 | 76.68 | 4.088 | 0.00001 | <0.00001 | 2.972 | 2.895 | |
Torque–length extension | rs13320 | 1q21.3 | 145.69 | 2.326 | 0.0005 | <0.0001 | 2.064 | 2.032 |
rs714513 | 2p23.3 | 50.2 | 2.690 | 0.0002 | <0.0001 | 2.654 | 2.627 | |
rs9328112 | 6p25.2 | 7.27 | 2.079 | 0.001 | <0.001 | 2.009 | 2.004 | |
rs1998825 | 10q26.3 | 166.36 | 1.877 | 0.002 | <0.001 | 1.733 | 1.725 | |
rs169631 | 12q24.31 | 141.2 | 1.751 | 0.002 | <0.001 | 1.308 | 1.291 | |
rs3785513 | 17q25.3 | 137.3 | 1.746 | 0.002 | <0.001 | 1.644 | 1.669 | |
rs1010800 | 18q11.2 | 43.66 | 2.205 | 0.0007 | <0.0001 | 2.173 | 2.175 | |
Additional >1.5 LOD regions after adjustment for covariates | ||||||||
MBA mid thigh | rs1880542 | 2q14.2 | 130.66 | 1.438 | — | — | — | 1.592* |
Torque at 30° flexion | rs2056865 | 7q31.2 | 122.77 | 1.140 | — | — | 1.522 | 1.516 |
rs8035183 | 15q23 | 74.51 | 0.262 | — | — | 1.853 | 1.777 | |
Torque at 60° extension | rs1556611 | 10q23.31 | 109.44 | 0.117 | — | — | 1.566 | 1.695 |
rs1941487 | 18p11.31 | 21.53 | 0.383 | — | — | 2.394 | 2.321 |
MBA, muscle and bone cross-sectional area of the mid thigh.
*Sport Index.