Table 3.
Antifungal Activity of Compounds 1, 3, and 6–9a
| compound | Candida albicans | Cryptococcus neoformans | Mycobacterium intracellulare | Aspergillus fumigatus | ||||
|---|---|---|---|---|---|---|---|---|
| IC50 | MIC | IC50 | MIC | IC50 | MIC | IC50 | MIC | |
| 1 | -b | - | 35 | - | - | - | 2.0 | - |
| 3 | - | - | - | - | - | - | 35 | - |
| 6 | 0.25 | 0.78 | - | - | - | - | - | - |
| 7 | 2.0 | 3.13 | 3.5 | 12.5 | 5.0 | 50 | - | - |
| 8 | 2.0 | 6.25 | 4.5 | 12.5 | 9.0 | 50 | - | - |
| 9 | 2.0 | 6.25 | 9.0 | 25 | 15.0 | - | - | - |
| Amphotericin Bd | 0.35 | 1.25 | 0.45 | 1.25 | NT | NT | 0.91 | 1.25 |
| Ciprofloxacind | NTc | NT | NT | NT | 0.30 | 0.63 | NT | NT |
a
IC50 and MIC (minimum inhibitory concentration) values are in μg/mL.
b
-: not active at the highest test concentration of 50 μg/mL.
c
NT: not tested
d
Positive control