Figure 3.
Time dependent transport of the compounds and SAHA across Caco-2 cells grown on inserts. Transport is expressed as nmol/ml. Data points represent both basolateral to apical (BL to AP) and apical to basolateral (AP to BL) transport. BL to AP transport of W2 (closed circles), S2 (closed squares) and SAHA (closed triangles) is illustrated. AP to BL transport of W2 (open circles), S2 (open squares) and SAHA (open triangles) is displayed. The data points represent the mean values ± S.E.M. of three independent experiments. Statistical analysis was carried out by the paired Student’s t-test (p<0.05). Upper panel, *, BL to AP transport of the compounds and SAHA is significantly higher than AP to BL; p<0.05. Lower panel, ‡, the transport of W2 is significant different from SAHA at a level of p<0.05.