Table 5.
Multivariate analysis of disease-free survival and overall survival in Stages II and III (n = 103)a
| Prognostic factors | Disease-free survival |
Overall survival |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P valueb | HR | 95% CI | P valueb | |
| Age | ||||||
| ≤62c | 1.00 | 1.00 | ||||
| >62 | 1.40 | 0.84–2.34 | 0.202 | 2.06 | 1.21–3.53 | 0.008 |
| Histologic type | ||||||
| Squamous | 1.00 | 1.00 | ||||
| Non-squamous | 2.84 | 1.65–4.89 | <0.0001 | 1.75 | 0.99–3.07 | 0.052 |
| Tumor size (cm) | ||||||
| ≤3.9d | 1.00 | 1.00 | ||||
| >3.9 | 2.00 | 1.26–3.20 | 0.004 | 1.94 | 1.18–3.19 | 0.009 |
| Stagee | ||||||
| II | 1.00 | 1.00 | ||||
| IIIA | 1.51 | 0.91–2.49 | 0.110 | 1.66 | 0.96–2.86 | 0.069 |
| IIIB | 1.83 | 0.93–3.57 | 0.079 | 2.29 | 1.15–4.56 | 0.019 |
| Resection margin | ||||||
| Negative | 1.00 | 1.00 | ||||
| Positive | 2.07 | 1.04–4.13 | 0.039 | 2.21 | 1.10–4.44 | 0.026 |
| Chemotherapy | ||||||
| Yes | 1.00 | 1.00 | ||||
| No | 1.55 | 0.98–2.45 | 0.061 | 1.47 | 0.89–2.45 | 0.136 |
| Expression of Bax | ||||||
| High | 1.00 | 1.00 | ||||
| Low | 2.51 | 1.35–4.66 | 0.004 | 1.77 | 0.92–3.40 | 0.086 |
aExcluding five patients who died of post-operative complication. bCox proportional-hazards regression model. cMedian age. dMedian longest diameter of primary tumor. ePost-operative pathologic staging.