Table 1.
Yeast AP subunits
| AP complex | Gene | Subunit | Most similar mammalian subunita | |
|---|---|---|---|---|
| AP-1 | APL2 | β1 | β1/2b | (38 /61)c |
| APL4 | γ | γ | (32 /50) | |
| APM1 | μ1 | μ1 | (49 /66) | |
| APS1 | ς1 | ς1 | (53 /73) | |
| (APM2) | ? | ? | ||
| AP-2R | APL1 | β2R | β1/2 | (32 /56) |
| APL3 | αR | α | (25 /43) | |
| APM4 | μ2R | μ2 | (33 /53) | |
| APS2 | ς2R | ς2 | (49 /70) | |
| AP-3 | APL6 | β3 | β3 | (28 /48) |
| APL5 | δ | δ | (29 /52) | |
| APM3 | μ3 | μ3 | (33 /41) | |
| APS3 | ς3 | ς3 | (46 /64) | |
b
β1 and β2 are too similar to distinguish in sequence comparisons to the yeast proteins. Sequence similarity refers to comparison to human β2.
c
Percentage of identical/similar amino acids in comparison of yeast sequences with human sequences. GenBank accession numbers: β2, 179333; γ, 2765190; μ1B, 4885427; ς1, 3641678; α, 4240287 (designated an α subunit based on sequence comparisons (Payne, unpublished data); μ2, 1665725; ς2, 1296607; β3A, 2199512; δ, 2290770; μ3A, 4426603; ς3A, 1923270. In all cases but Apm3p sequence similarity extends over at least 80% of the yeast protein. The similarity between Apm3p and μ3A extends over the C-terminal 60% of the protein, beginning at residue 199 in Apm3p.