TABLE I.

Summary of correlation HeatMap data representing differential expression analysis in cancerversus normal controls from independent studies analyzing LPA1 mRNA

Normal or Cancer type (no. samples)	Differential Expression
	High	Low	Neutral	Study
Brain
Normal brain (6)	6	0	0	[19]
Anaplastic Oligoastrocytoma (4)	1	1	2	[19]
Anaplastic Oligodendroglioma (23)	4	10	9	[19]
Normal brain, epilepsy (23)	19	4	0	[20]
Astrocytoma (26)	7	8	11	[20]
Glioblastoma multiforme (77)	18	18	41	[20]
Oligodendroglioma (50)	9	19	22	[20]
Normal brain (4)	4	0	0	[21]
Anaplastic Oligoastrocytoma (6)	2	1	3	[21]
Glioblastoma (31)	11	8	13	[21]
Oligodendroglioma (8)	1	4	3	[21]
Astrocytic Tumor (5)	0	2	3	[21]
Breast
Normal (7)	5	0	2	[22]
Breast carcinoma (40)	6	10	24	[22]
Liver
Non-tumor liver (76)	8	7	61	[23]
Benign liver disease (7)	2	2	3	[23]
Metastatic liver cancer (10)	6	2	2	[23]
Hepatocellular carcinoma (104)	17	40	47	[23]
Melanoma
Normalskin (7)	7	0	0	[24]
Benign Nevus (18)	16	0	2	[24]
Melanoma (45)	3	23	19	[24]
Normal mole (10)	9	1	0	[25]
Primary melanoma (5)	0	0	5	[25]
Metastatic melanoma (17)	1	9	7	[25]
Ovarian
Normal ovary (4)	4	0	0	[26]
Ovarian clear cell adenocarcinoma (8)	0	6	2	[26]
Ovarian endometrioid adenocarcinoma (37)	8	7	22	[26]
Ovarian mucinous adenocarcinoma (13)	1	4	8	[26]
Ovarian serous adenocarcinoma (41)	9	13	19	[26]
Prostate
Normal prostate (23)	15	0	8	[27]
Prostate carcinoma (64)	13	22	29	[27]
Metastatic prostate cancer (25)	0	18	7	[27]
Seminoma
Normal testis (6)	0	6	0	[28]
Adult male germ cell tumor (91)	23	27	41	[28]
Adult male germ cell tumor metastases (7)	2	4	1	[28]