Skip to main content
. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Exp Mol Pathol. 2008 Apr 8;85(1):20–27. doi: 10.1016/j.yexmp.2008.03.004

Fig. 2. TLR2−/− mice with the scid mutation (TLR2−/−/scid) harbor increased levels of spirochetes with reduced arthritis severity.

Fig. 2

A. Enumeration of B. burgdorferi numbers within the rear ankle joints of wildtype and immunodeficient mice was conducted at 2,4, and 8 weeks post-infection by quantitative PCR. Values are expressed as number of B. burgdorferi genomes/1000 mouse genomes. Statistical significance was assessed by one-way analysis of variance followed by Tamhane post hoc multiple comparison. P < 0.05 was considered significant. * indicates values for immunodeficient mice that were significantly greater versus wildtype mice. ‡ indicates values for wildtype and singly immunodeficient mice that were significantly less than those for TLR2−/−/scid mice. B. Assessment of rear ankle swelling in B. burgdorferi-infected mice. Values obtained at 4 wks post-infection were subtracted from those obtained prior to infection (Yang et al., 1992). Statistical significance was assessed by one-way analysis of variance followed by Tamhane post hoc multiple comparison. P < 0.05 was considered significant. * indicates significantly greater ankle swelling in TLR2−/− mice versus all other mice (Wang et al., 2005). Copyright 2005 American Society for Microbiology, used with permission.