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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Exp Mol Pathol. 2008 Apr 8;85(1):20–27. doi: 10.1016/j.yexmp.2008.03.004

Fig. 6. The phenotypes observed by microarray analysis correlate with the inflammatory status of the joint and not with the mouse strain.

Fig. 6

A. Ankle swelling, an indicator of arthritis severity was measured in C3H, C57BL/6, and IL-10−/− mice at 1, 2, and 4 weeks post-B. burgdorferi infection. C3H mice develop severe arthritis, C57BL/6 mice get mild arthritis, and IL-10−/− mice exhibit an intermediate arthritis phenotype. B. The IFN profile induced in C3H mice at 1 week post-infection returns to baseline by 2 weeks after infection, whereas IL-10−/− mice are delayed in induction of this profile, exhibiting upregulation of IFN-responsive genes at 2 weeks post-infection. C. C57BL/6 mice maintain induction of the epidermal profile at 2 weeks post-infection, while this profile remains suppressed in C3H and IL-10−/− mice (Crandall et al., 2006). Copyright 2006 The American Association of Immunologists, Inc., used with permission.