Figure 7.

Serum Transaminase Levels After A Single Dose of Adenovirus. Alanine aminotransferase (ALT) levels following administration of: wild type adenovirus 5 (WT), first generation adenovirus expressing beta-galactosidase (AdlacZ), PEGylated AdlacZ, (PEGAd), helper-dependent virus expressing beta-galactosidase (HDAd), or inactivated virus (UVAd). For all panels, animals dosed with phosphate buffered saline served as controls (Vehicle). Values are presented as the mean ± standard error of 4 animals/treatment/timepoint. Statistical significance was determined between individual treatment groups and vehicle controls by one-way analysis of variance with a Bonferroni/Dunn post-hoc test. *p ≤ 0.05, **p ≤ 0.01