Table 1. Association between total IgE and selected SNPs in the GWAS sample and in the four replication samples.

		GWAS KORA S3/F3			Replication KORA S4			Replication GINI			Replication LISA			Replication ISAAC			Combined
		n = 1,530			n = 3,890			n = 1,839			n = 1,042			n = 2,998			n = 9,769
Gene	SNP	Est.	P value	Est. %	Est.	P value	Est. %	Est.	P value	Est. %	Est.	P value	Est. %	Est.	P value	Est. %	Est.	P value	Est. %
FCER1A	rs2511211				−0.206	9.28E-08	−18.59
FCER1A	rs10489854				0.153	2.85E-02	16.52
FCER1A	rs2494262				0.122	1.67E-04	12.99
FCER1A	rs2427837	−0.235	6.19E-05	−20.94	−0.212	3.23E-09	−19.12	−0.219	2.51E-05	−19.64	−0.280	6.58E-05	−24.56	−0.145	4.27E-04	−13.53	−0.202	7.08E-19	−18.27
FCER1A	rs12565775				0.119	2.45E-02	12.56
FCER1A	rs2427824				0.082	2.52E-02	8.49
FCER1A	rs3845625				0.085	5.09E-02	8.82
FCER1A	rs2427827				0.120	2.45E-04	12.72
FCER1A	rs2251746				−0.227	6.07E-10	−20.29	−0.236	8.14E-06	−20.99	−0.290	4.18E-05	−25.17	−0.153	2.11E-04	−14.16	−0.213	1.85E-20	−19.21
RAD50	rs2069812				−0.052	1.42E-01	−4.98
RAD50	rs2706347	0.236	4.05E-05	26.62	0.143	2.26E-04	15.43	0.122	2.91E-02	13.02	0.118	1.01E-01	12.56	0.095	2.70E-02	9.96	0.120	6.28E-07	12.80
RAD50	rs6884762				0.034	7.22E-01	3.46
RAD50	rs17772565				−0.096	2.27E-01	−9.17
RAD50	rs17772583				−0.058	1.24E-01	−5.62
RAD50	rs3798135	0.227	6.58E-05	25.48	0.142	2.32E-04	15.20	0.173	2.00E-03	18.91	0.107	1.37E-01	11.26	0.101	1.75E-02	10.64	0.129	6.69E-08	13.82
RAD50	rs2040704	0.221	9.25E-05	24.73	0.140	2.47E-04	14.97	0.158	4.40E-03	17.14	0.111	1.21E-01	11.73	0.112	8.22E-03	11.83	0.130	4.46E-08	13.90
RAD50	rs7737470	0.231	4.81E-05	25.99	0.142	2.27E-04	15.28	0.163	3.70E-03	17.70	0.100	1.64E-01	10.55	0.087	4.13E-02	9.12	0.123	3.35E-07	13.07
RAD50	rs2240032				0.137	4.01E-04	14.67
RAD50	rs2214370				0.136	5.95E-01	14.54
STAT6	rs12368672	0.167	8.52E-04	18.18	0.156	2.03E-06	16.93	0.016	7.34E-01	1.65	0.075	2.44E-01	7.78				0.108	1.52E-05	11.44