Table 3. Progressive changes in haematology indices of vervet monkeys infected with T.b. rhodesiense cloned strains through cyclic (tsetse; Glossina pallidipes) transmission.
| Parameters | T.b. rhodesiense KETRI 3741 | T.b. rhodesiense KETRI 3801 | T.b. rhodesiense. KETRI 3804 | T.b.rhodesiense KETRI 3928 | |||||
| a476F | a515M | a536M | a523F | a579M | a556F | a574M | a554F | a555M | |
| Red blood cells (countsx106/µl): pre-infection level | 5.21 | 5.71 | 6.35 | 6.16 | 6.28 | 5.48 | 6.51 | 5.39 | 7.34 |
| Red blood cells: % reduction at 32dpi | 23.4 | 25.7 | 53.5 | 48.9 | 44.4 | 29.7 | 26.7 | 21.3 | 24.8 |
| Red blood cells: % reduction at extremis | 55.9 | 15.4 | 53.5 | 49.0 | 71.4 | 52.2 | 13.2 | 57.9 | |
| Haematocrit (%): pre-infection level | 40.6 | 46.6 | 51.4 | 48.3 | 48.3 | 40.2 | 52.1 | 41.7 | 57.2 |
| Haematocrit (%): % reduction at 32 dpi | 33.3 | 33.3 | 59.5 | 47.8 | 45.8 | 30.3 | 35.1 | 26.9 | 32.9 |
| Haematocrit (%): % reduction at extremis | 56.2 | 31.1 | 55.1 | 50.0 | 68.7 | 59.9 | 24.5 | 63.1 | |
| Haemoglobin (g/dl): Pre-infection level | 12.2 | 14.3 | 16.4 | 14.2 | 14.2 | 11.8 | 15.2 | 12.1 | 16.9 |
| Haemoglobin: % reduction at 32 dpi | 25.4 | 31.5 | 57.3 | 45.8 | 45.1 | 30.5 | 34.9 | 24.8 | 32.0 |
| Haemoglobin: % reduction at extremis | 58.2 | 21.7 | 57.9 | 47.9 | 67.8 | 59.2 | 17.4 | 62.1 | |
| Mean corpuscular volume (fl): Pre-infection level | 77.8 | 81.6 | 80.9 | 78.4 | 76.8 | 73.5 | 79.9 | 77.4 | 77.9 |
| Mean corpuscular volume: % change at 32 dpi | −12.6 | −9.9 | −12.6 | +2.0 | −2.5 | −1.1 | −11.1 | −6.8 | −0.7 |
| Mean corpuscular volume: % change at extremis | −0.9 | −11.3 | +1.1 | −1.6 | +9.5 | −15.6 | −12.9 | −12.5 | |
| Mean corpuscular haemoglobin (pg): Pre-infection level | 23.4 | 25.1 | 25.6 | 23.1 | 22.6 | 21.6 | 23.3 | 22.4 | 23.1 |
| Mean corpuscular haemoglobin: % change at 32 dpi | −3.0 | −8.0 | −7.8 | +6.5 | −0.4 | −1.4 | −10.3 | −4.0 | −10.0 |
| Mean corpuscular haemoglobin: % change at extremis | −5.6 | −7.6 | −5.8 | +2.7 | +13.0 | −13.7 | −4.9 | −9.5 | |
| Red cell distribution width (%): pre-infection level | 13.4 | 13.7 | 11.8 | 14.8 | 13.6 | 13.5 | 11.9 | 12.4 | 12.6 |
| Red cell distribution width: % increase at 32 dpi | 29.9 | 56.9 | 61.9 | 17.6 | 61.0 | 57.0 | 46.2 | 46.8 | 34.9 |
| Red cell distribution width: % increase at extremis | 56.7 | 36.5 | 57.6 | 77.9 | 79.3 | 68.9 | 93.5 | 50.0 | |
| Platelets (counts/µl): Pre-infection level | 461 | 281 | 307 | 330 | 331 | 457 | 266 | 374 | 341 |
| Platelets: % reduction at 32 dpi | 38.8 | 7.7 | 71.7 | 99.1 | 77.6 | 78.1 | 68.8 | 53.5 | 76.2 |
| Platelets: % reduction at extremis | 76.4 | 30.0 | 78.5 | 82.8 | 98.0 | 89.1 | 97.9 | 94.4 | |
| Mean platelet volume (fl): pre-infection values | 7 | 6.3 | 6.9 | 7 | 7.7 | 7.6 | 6.7 | 7.3 | 6.3 |
| Mean platelet volume: % increase at 32 dpi | 17.1 | 23.8 | 50.7 | 87.4 | 53.2 | NDA | 55.3 | 17.1 | 54 |
| Mean platelet volume : % increase at extremis | 45.7 | 47.6 | 60.9 | 49.4 | 55.3 | NDA | 41.1 | 85.7 | |
Key: dpi = days post infection; T.b.r. = Trypanosoma brucei rhodesiense; a = Laboratory number of monkey; F = Female; M = Male; O = observed; NO = Not observed; fl = femtolitres; pg = picograms; g/dl = grams per decilitre; − = decreased; + = increased; NDA = No data available.