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. 2008 Jul 21;52(10):3648–3663. doi: 10.1128/AAC.01230-07

TABLE 3.

Effects of sub-MICs of AZM, CFT, and CPR on P. aeruginosa genes belonging to the QS regulona

Gene in P. aeruginosa Gene pprBb Regulation by AZMc Reg.d Relative expression
 Description
AZM (2 μg/ml) AZM (8 μg/ml) CFT CPR lasl-rhlI lasR-rhlR lasR rhlR
PA0059 osmC C −19.8 −63.4 −8.6 −16.8 −22.0 −31.8 −44.0 −25.8 Osmotically inducible protein OsmC
PA0105 coxB C −20.0 −25.3 −8.3 −10.5 −11.5 −13.5 −18.7 −7.9 Cytochrome c oxidase, subunit II
PA0107 C −91.9 −29.0 −11.0 −17.0 −17.4 −14.1 −18.6 −11.4 Conserved hypothetical protein
PA0108 colII C −14.2 −33.8 −13.2 −12.2 −27.8 −8.5 −15.8 −6.3 Cytochrome oxidase, subunit III
PA0122 − C −3.0 −14.2 −1.5 −2.9 −44.8 −26.1 −7.1 −6.0 Conserved hypothetical protein
PA0188 C −2.9 −32.5 −4.8 −4.6 −8.1 −21.3 −28.2 −8.8 Hypothetical protein
PA0355 pfpl C −7.5 −12.5 −3.6 −6.6 −11.8 −21.5 −17.7 −11.6 Protease Pfpl
PA0567 C −9.2 −22.0 −3.5 −9.1 −249.4 −25.2 −22.1 −9.5 Conserved hypothetical protein
PA0572 A −3.5 −6.0 −2.3 −3.4 −10.4 −13.7 −8.2 −1.1 Hypothetical protein
PA0737 C −3.3 −3.4 −4.1 −4.3 −9.4 −7.7 −94.4 −5.8 Hypothetical protein
PA0843 plcR A −4.7 −7.8 −2.7 −3.3 −7.1 −6.2 −25.0 −4.6 Phospholipase accessory protein PlcR precursor
PA0852 cbpD − C −7.0 −35.0 −5.0 −10.1 −63.7 −74.4 −33.2 −8.3 Chitin-binding protein CbpD precursor
PA0990 A −7.0 −9.3 −3.3 −5.9 −5.7 −19.9 −6.6 −4.4 Conserved hypothetical protein
PA0996 pqsA − + A 2.0 1.7 1.3 −1.3 −7.0 −20.8 −34.5 3.3 Probable coenzyme A ligase
PA0997 pqsB − A 1.2 −1.2 1.1 −1.0 −12.6 −15.4 −59.2 3.1 Homologous to beta-keto-acyl-acyl carrier protein synthase
PA0998 pqsC − A 1.2 −1.3 1.2 −1.1 −8.2 −13.9 −29.9 2.8 Homologous to beta-keto-acyl-acyl carrier protein synthase
PA0999 pqsD − A 1.6 −1.2 −1.0 −1.3 −8.2 −9.8 −20.2 2.6 3-Oxoacyl-[acyl carrier protein] synthase III
PA1000 pqsE A 2.1 1.1 1.4 1.3 −7.9 −12.0 −28.9 3.6 Quinolone signal response protein
PA1001 phnA − A 1.9 1.0 −1.0 −1.6 −6.6 −9.7 −20.9 3.2 Anthranilate synthase component I
PA1002 phnB A 1.5 −1.1 1.2 −1.3 −7.3 −5.2 −6.3 5.5 Anthranilate synthase component II
PA1131 B −1.9 −5.2 −1.4 −2.4 −5.9 −11.1 −2.9 −6.6 Probable major facilitator superfamily transporter
PA1168 A −6.5 −8.1 −3.8 −3.3 −21.5 −19.1 −26.6 −3.9 Hypothetical protein
PA1190 C −19.2 −26.3 −9.8 −8.9 −14.6 −12.4 −12.5 −10.4 Conserved hypothetical protein
PA1242 C −5.7 −10.1 −5.5 −18.7 −19.6 −21.3 −6.7 −9.2 Hypothetical protein
PA1249 aprA D −23.5 −54.2 −3.5 −5.3 −7.3 −8.4 −4.1 −2.7 Alkaline metalloproteinase precursor
PA1250 aprl D −1.2 −1.5 1.1 −1.5 −9.7 −5.5 −3.0 −1.0 Alkaline proteinase inhibitor Aprl
PA1323 C −11.2 −35.6 −4.3 −9.6 −25.3 −39.3 −56.5 −15.5 Hypothetical protein
PA1324 C −10.5 −23.4 −4.8 −8.1 −22.1 −26.7 −39.2 −17.0 Hypothetical protein
PA1412 C −5.5 −11.2 −22.3 −7.0 −5.7 −5.6 −8.8 −6.6 Hypothetical protein
PA1431 rsaL − A −2.6 −2.2 −1.3 −2.2 −3,619.1 −3,441.9 −3,038.0 −1.9 Regulatory protein RsaL
PA1432 lasl − A −1.9 1.2 1.8 1.7 −97.0 −133.1 −39.0 −1.5 Autoinducer synthesis protein LasI
PA1471 C −4.5 −5.8 −2.0 −2.9 −7.8 −5.6 −10.3 −9.7 Hypothetical protein
PA1556 C 15.6 17.5 9.9 9.2 7.9 6.0 7.8 5.3 Probable cytochrome c oxidase subunit
PA1625 C −3.7 −5.1 −3.7 −7.4 −6.6 −9.0 −6.5 −5.5 Conserved hypothetical protein
PA1657 C 1.6 −1.5 −1.5 3.5 −12.7 −15.4 −12.7 −5.2 Conserved hypothetical protein
PA1662 D −1.5 −3.5 −2.3 −1.4 −5.7 −9.0 −4.3 −4.4 Probable ClpA/B-type protease
PA1664 − C 1.6 −2.4 −1.3 1.1 −5.2 −11.0 −15.5 −8.7 Hypothetical protein
PA1665 A 1.1 −2.7 −2.5 1.1 −5.6 −46.9 −15.1 −2.8 Hypothetical protein
PA1667 A −1.5 −4.1 −1.1 −1.1 −5.5 −5.1 −5.0 −3.1 Hypothetical protein
PA1669 B −6.3 −2.8 −2.0 −1.4 −28.6 −12.7 −3.8 −10.3 Hypothetical protein
PA1784 A −5.5 −14.6 −2.4 −4.4 −9.4 −11.2 −9.9 −1.4 Hypothetical protein
PA1869 − C 1.2 −3.2 −1.0 −2.7 −137.1 −287.9 −23.6 −25.1 Probable acyl carrier protein
PA1870 − C −4.3 −11.8 −6.9 −4.8 −22.0 −12.7 −8.8 −13.8 Hypothetical protein
PA1871 lasA − − C −10.3 −32.9 −2.9 −9.0 −105.4 −147.8 −31.3 −7.1 LasA protease precursor
PA1874 A −7.8 −9.3 −6.0 −6.6 −8.0 −6.4 −7.9 1.9 Hypothetical protein
PA1875 A −7.5 −16.7 −12.3 −20.5 −34.2 −9.0 −6.7 1.1 Probable outer membrane protein precursor
PA1901 phzC2 − C −1.4 −27.6 −3.1 −4.1 −21.8 −25.3 −19.1 −51.2 Phenazine biosynthesis protein PhzC
PA1902 phzD2 − C −1.3 −42.9 −3.5 −4.5 −133.5 −132.0 −97.7 −91.0 Phenazine biosynthesis protein PhzD
PA1903 phzE2 − C −1.3 −20.0 −2.7 −4.5 −17.2 −24.4 −18.6 −19.7 Phenazine biosynthesis protein PhzE
PA1904 phzF2 − C 1.1 −20.8 −3.5 −3.8 −134.0 −61.6 −77.4 −44.7 Probable phenazine biosynthesis protein
PA1905 phzG2 − C 1.2 −15.9 −2.6 −4.4 −14.1 −32.7 −20.8 −30.0 Probable pyridoxamine 5′-phosphate oxidase
PA1914 A −24.0 −31.9 −5.5 −6.8 −92.8 −15.1 −100.0 −1.4 Conserved hypothetical protein
PA2021 C −12.2 −14.1 −5.0 −11.5 −8.6 −12.1 −12.2 −13.2 Hypothetical protein
PA2046 C −5.9 −25.2 −5.9 −8.6 −32.6 −22.1 −38.7 −45.5 Hypothetical protein
PA2067 A −3.5 −13.4 −2.1 −5.9 −6.0 −5.7 −5.3 −4.2 Probable hydrolase
PA2068 − C −3.2 −13.4 −1.8 −5.5 −8.5 −19.4 −18.5 −25.0 Probable major facilitator superfamily transporter
PA2069 − C −4.2 −70.4 −2.3 −6.7 −29.3 −72.9 −26.1 −26.8 Probable carbamoyl transferase
PA2137 C −29.3 −107.3 −50.3 −20.8 −11.4 −15.9 −46.4 −71.3 Hypothetical protein
PA2139 C −28.3 −20.2 −14.1 −20.7 −9.5 −10.0 −7.7 −24.3 Hypothetical protein
PA2141 C −31.2 −23.4 −8.2 −33.2 −5.8 −45.3 −80.1 −69.0 Hypothetical protein
PA2142 C −27.1 −18.9 −12.3 −19.5 −13.4 −16.4 −18.2 −26.8 Probable short-chain dehydrogenase
PA2143 C −82.1 −43.2 −23.0 −42.5 −67.1 −60.1 −191.3 −83.7 Hypothetical protein
PA2144 glgp A −11.0 −22.1 −6.9 −7.4 −7.3 −20.8 −11.4 −4.8 Glycogen phosphorylase
PA2146 − C −8.5 −11.4 −8.0 −7.4 −6.9 −10.8 −15.5 −9.7 Conserved hypothetical protein
PA2148 A −5.3 −8.0 −4.5 −5.5 −8.1 −8.1 −6.4 −4.0 Conserved hypothetical protein
PA2149 C −6.7 −10.6 −4.5 −12.3 −6.3 −7.0 −39.5 −11.2 Hypothetical protein
PA2151 C −47.9 −71.1 −11.2 −13.5 −39.3 −124.4 −41.2 −30.6 Conserved hypothetical protein
PA2153 glgB C −15.0 −30.0 −4.2 −6.4 −6.9 −11.3 −19.1 −9.2 1,4-Alpha-glucan branching enzyme
PA2158 C −23.8 −68.3 −12.3 −43.9 −65.0 −10.3 −35.9 −52.4 Probable alcohol dehydrogenase (Zn dependent)
PA2163 C −9.0 −9.6 −3.9 −7.9 −8.2 −8.2 −6.9 −5.3 Hypothetical protein
PA2165 C −16.5 −19.7 −7.5 −14.4 −8.7 −5.4 −6.2 −7.5 Probable glycogen synthase
PA2166 C −15.8 −19.0 −6.7 −14.8 −15.4 −38.5 −24.4 −19.2 Hypothetical protein
PA2167 C −11.0 −86.2 −7.4 −18.1 −8.7 −8.1 −7.1 −15.4 Hypothetical protein
PA2170 C −4.1 −5.1 −3.1 −8.6 −8.2 −14.1 −5.4 −6.5 Hypothetical protein
PA2171 − C −10.1 −9.9 −7.0 −21.7 −27.6 −109.9 −58.6 −22.5 Hypothetical protein
PA2176 C −50.5 −112.3 −10.0 −14.8 −19.2 −25.2 −30.0 −12.0 Hypothetical protein
PA2178 D −7.0 −3.6 −3.6 −21.9 −11.2 −6.3 −4.3 −4.9 Hypothetical protein
PA2184 C −5.0 −6.7 −4.7 −7.3 −15.5 −13.9 −17.5 −20.8 Conserved hypothetical protein
PA2190 − C −13.3 −60.5 −6.3 −11.3 −17.0 −14.9 −9.9 −6.9 Conserved hypothetical protein
PA2193 hcnA − + B 3.5 −1.5 1.7 1.4 −262.2 −256.6 −3.0 −9.1 Hydrogen cyanide synthase HcnA
PA2194 hcnB − B 2.3 −3.9 −1.1 −1.3 −123.1 −43.1 −2.3 −8.3 Hydrogen cyanide synthase HcnB
PA2195 hcnC − B 1.7 −4.3 1.1 −1.5 −20.5 −38.9 −2.7 −6.9 Hydrogen cyanide synthase HcnC
PA2300 chiC − C −20.2 −45.4 −8.1 −20.7 −33.8 −66.7 −82.8 −34.0 Chitinase
PA2302 − A −3.3 −9.6 −1.8 −3.3 −13.2 −17.5 −10.1 −1.2 Probable nonribosomal peptide synthetase
PA2303 − A −3.1 −10.5 −1.5 −2.1 −87.9 −212.8 −59.2 −1.3 Hypothetical protein
PA2304 − A −2.8 −6.9 −1.5 −2.3 −18.1 −23.2 −9.2 1.1 Hypothetical protein
PA2305 A −1.7 −2.8 1.1 −1.5 −6.5 −16.7 −8.8 1.1 Probable nonribosomal peptide synthetase
PA2414 C −12.2 −51.7 −4.6 −11.3 −32.2 −17.6 −16.4 −7.7 l-Sorbosone dehydrogenase
PA2415 C −5.1 −8.6 −2.9 −6.4 −13.8 −9.3 −9.2 −5.2 Hypothetical protein
PA2423 + A −1.2 −1.2 −1.1 −1.6 −5.8 −5.9 −7.6 1.6 Hypothetical protein
PA2433 C −25.6 −70.7 −6.4 −24.8 −25.9 −67.3 −70.0 −32.8 Hypothetical protein
PA2485 + C −7.9 −8.1 −2.3 −7.0 −12.0 −18.0 −15.5 −12.3 Hypothetical protein
PA2486 C −9.3 −18.4 −2.3 −4.5 −8.9 −10.6 −8.5 −5.7 Hypothetical protein
PA2566 A −4.2 −6.8 1.1 −3.3 −9.6 −7.1 −6.3 −1.7 Conserved hypothetical protein
PA2570 lecA C −25.9 −76.4 −4.5 −14.9 −45.4 −49.2 −27.2 −30.3 LecA
PA2587 pqsH − A −1.6 −2.1 −1.6 −2.3 −46.1 −36.1 −20.4 1.3 Probable FAD-dependent mono-oxygenase
PA2588 A −3.3 −4.5 −2.4 −4.3 −6.7 −34.3 −87.8 −2.4 Probable transcriptional regulator
PA2591 D −1.1 −1.2 1.1 −1.3 −7.1 −14.8 −2.2 1.1 Probable transcriptional regulator
PA2592 D 1.3 −1.2 1.4 −1.1 −6.7 −17.9 −3.8 −1.6 Probable periplasmic spermidine/putrescine-binding protein
PA2708 C −4.1 −4.7 −4.2 −6.1 −5.8 −7.8 −8.7 −12.5 Hypothetical protein
PA2747 + C −3.8 −7.2 −2.6 −7.7 −32.6 −37.3 −37.5 −10.3 Hypothetical protein
PA2751 C −3.4 −4.4 −2.4 −4.3 −8.5 −7.0 −10.3 −6.0 Conserved hypothetical protein
PA2754 C −5.0 −9.2 −2.4 −3.5 −11.5 −7.3 −9.1 −5.4 Conserved hypothetical protein
PA2777 C −4.4 −26.5 −4.6 −10.1 −8.4 −6.2 −10.5 −8.9 Conserved hypothetical protein
PA2873 D −1.2 −7.8 −1.3 −3.1 −13.2 −5.8 −1.6 −1.3 Hypothetical protein
PA2937 C −23.3 −45.2 −5.2 −13.2 −6.9 −8.6 −9.1 −5.4 Hypothetical protein
PA2939 − A −10.6 −38.6 −3.5 −6.5 −39.8 −9.1 −12.7 1.8 Probable aminopeptidase
PA3231 C −17.7 −21.9 −6.4 −41.9 −33.7 −13.2 −27.7 −10.0 Hypothetical protein
PA3273 C −10.2 −20.7 −4.0 −19.7 −13.3 −13.2 −13.2 −27.1 Hypothetical protein
PA3274 C −11.5 −49.1 −7.0 −27.4 −45.1 −37.5 −112.5 −17.5 Hypothetical protein
PA3326 D −1.5 −4.2 1.3 −1.0 −12.3 −11.0 −2.4 −4.1 Probable Clp family ATP-dependent protease
PA3327 − C −1.4 −5.0 −1.0 1.3 −5.4 −12.7 −5.0 −9.8 Probable nonribosomal peptide synthetase
PA3328 − B −1.3 −4.5 −1.1 −1.2 −6.5 −26.0 −3.2 −12.4 Probable FAD-dependent mono-oxygenase
PA3329 − C 1.3 −3.8 1.9 1.3 −54.9 −173.5 −6.1 −69.3 Hypothetical protein
PA3330 − B −4.3 −1.1 1.7 1.3 −62.4 −179.6 −4.4 −19.5 Probable short-chain dehydrogenase
PA3331 − B 1.1 −4.1 1.8 1.6 −19.8 −62.0 −3.8 −23.8 Cytochrome P450
PA3332 − B 1.3 −4.3 1.3 1.2 −10.2 −18.7 −5.0 −17.7 Conserved hypothetical protein
PA3333 fabH2 − B −1.3 −7.4 1.0 −1.2 −17.0 −33.4 −4.1 −10.4 3-Oxoacyl-[acyl carrier protein] synthase III
PA3334 − C 1.2 −3.8 1.8 1.7 −42.8 −17.4 −5.1 −11.2 Probable acyl carrier protein
PA3335 − D 1.1 −3.9 1.8 1.2 −18.4 −9.4 −2.3 −3.9 Hypothetical protein
PA3336 B −9.3 −2.4 1.5 −1.3 −8.2 −9.3 −4.3 −22.8 Probable major facilitator superfamily transporter
PA3361 lecB C −1.4 −12.3 −1.6 −2.5 −22.4 −28.9 −13.2 −15.3 Fucose-binding lectin PA-IIL
PA3369 + C −7.1 −11.9 −4.2 −12.7 −19.9 −42.2 −36.5 −14.2 Hypothetical protein
PA3370 + C −12.9 −26.1 −8.7 −37.1 −39.0 −66.4 −87.1 −31.2 Hypothetical protein
PA3371 + C −6.7 −11.7 −7.4 −18.8 −23.8 −51.7 −69.2 −25.7 Hypothetical protein
PA3460 A −12.9 −28.0 −2.0 −3.2 −5.0 −6.0 −7.0 −4.7 Probable acetyltransferase
PA3476 rhll − D −1.6 −2.0 −1.2 −1.6 −19.0 −41.4 −2.4 −1.8 Autoinducer synthesis protein Rhll
PA3478 rhlB − C −7.3 −31.7 −2.4 −6.3 −120.2 −122.7 −19.5 −53.0 Rhamnosyltransferase chain B
PA3479 rhlA − C −5.0 −28.3 −1.8 −5.3 −320.2 −196.0 −14.5 −55.0 Rhamnosyltransferase chain A
PA3520 C −3.7 −8.9 −2.7 −4.4 −28.3 −18.3 −13.9 −7.4 Hypothetical protein
PA3581 glpF C −163.4 −43.8 −14.0 −99.3 −61.0 −88.9 −19.1 −35.1 Glycerol uptake facilitator protein
PA3584 glpD C −9.2 −12.2 −8.1 −6.3 −5.7 −20.4 −12.0 −8.4 Glycerol-3-phosphate dehydrogenase
PA3691 C −5.1 −13.3 −2.0 −3.1 −11.6 −19.2 −28.8 −12.3 Hypothetical protein
PA3692 C −7.9 −26.7 −3.1 −4.4 −30.7 −16.8 −37.5 −12.3 Probable outer membrane protein precursor
PA3724 lasB − C −3.5 −22.8 −2.5 −6.1 −167.2 −224.3 −15.1 −5.2 Elastase LasB
PA3734 C −5.0 −9.3 −3.5 −4.9 −7.2 −21.3 −6.6 −8.5 Hypothetical protein
PA3788 A −4.7 −6.5 −2.7 −4.8 −9.2 −5.8 −6.1 −4.0 Hypothetical protein
PA3819 C −3.5 −5.0 −3.7 −3.6 −6.3 −7.0 −9.7 −7.1 Conserved hypothetical protein
PA3888 A −2.5 −3.2 −2.1 −3.5 −5.8 −10.2 −10.5 −4.6 Probable permease of ABC transporter
PA3890 C −3.8 −5.1 −2.6 −6.7 −17.8 −87.2 −64.7 −31.8 Probable permease of ABC transporter
PA3904 − A 1.9 1.5 1.5 1.6 −68.3 −40.7 −172.1 −1.0 Hypothetical protein
PA3906 − A 1.1 −1.2 −1.2 −1.1 −7.5 −176.5 −9.5 −1.4 Hypothetical protein
PA3907 A 1.4 −1.1 1.2 2.0 −5.8 −13.4 −5.2 1.0 Hypothetical protein
PA3908 − D −1.0 −2.6 −1.5 1.2 −6.2 −49.8 −4.5 1.1 Hypothetical protein
PA4078 * A −6.2 −15.8 −4.3 −6.4 −5.6 −11.0 −7.4 −4.8 Probable nonribosomal peptide synthetase
PA4130 − D 1.4 −1.9 −1.3 1.1 −9.6 −6.2 −3.3 1.5 Probable sulfite or nitrite reductase
PA4133 − A 2.6 −1.8 −2.1 1.1 −57.4 −13.0 −6.1 1.6 Cytochrome c oxidase subunit (cbb3 type)
PA4134 − A 1.9 −3.3 −3.3 −1.8 −12.0 −5.6 −18.0 −1.2 Hypothetical protein
PA4139 A −9.2 −11.6 −4.3 −3.2 −6.1 −10.2 −7.0 −4.2 Hypothetical protein
PA4141 − C −2.0 −12.2 −1.1 −1.6 −73.1 −105.0 −27.6 −57.6 Hypothetical protein
PA4142 C −2.1 −11.7 −2.1 −4.2 −27.2 −71.7 −25.6 −26.4 Probable secretion protein
PA4143 C −2.6 −14.4 −2.1 −3.4 −8.1 −15.3 −7.3 −9.0 Probable toxin transporter
PA4171 C −7.4 −10.0 −4.9 −6.3 −5.4 −15.5 −13.6 −9.5 Probable protease
PA4175 prpL A −12.0 −25.4 −6.7 −15.8 −28.4 −47.1 −30.4 −1.6 Pvds-regulated endoprotease, lysyl class
PA4209 phzM C 1.8 −10.8 −1.9 −1.9 −9.8 −18.8 −11.9 −7.5 Probable phenazine-specific methyltransferase
PA4210 phzA1 C −1.0 −11.8 −2.3 −5.6 −65.1 −123.9 −79.7 −20.2 Probable phenazine biosynthesis protein
PA4211 phzB1 − C 1.4 −15.5 −2.2 −2.3 −51.0 −61.2 −59.7 −46.1 Probable phenazine biosynthesis protein
PA4217 phzS − C 1.4 −9.6 −2.2 −2.2 −11.4 −12.9 −8.9 −10.9 Flavin-containing mono-oxygenase
PA4290 C −23.4 −19.0 −26.8 −25.3 −7.2 −6.0 −14.2 −15.9 Probable chemotaxis transducer
PA4345 C −5.3 −7.4 −3.9 −6.9 −10.6 −9.1 −7.7 −6.6 Hypothetical protein
PA4377 − A −13.9 −12.2 −3.5 −6.2 −10.1 −7.0 −7.8 −3.2 Hypothetical protein
PA4677 A −6.8 −4.2 −3.1 −5.1 −17.0 −40.0 −22.5 −1.1 Hypothetical protein
PA4738 C −6.8 −22.5 −5.2 −11.5 −39.6 −54.4 −58.1 −16.6 Conserved hypothetical protein
PA4739 − C −4.8 −12.9 −3.4 −5.7 −34.3 −34.3 −43.8 −16.6 Conserved hypothetical protein
PA4876 osmE C −5.3 −10.4 −3.4 −4.8 −18.2 −9.1 −10.8 −6.7 Osmotically inducible lipoprotein Osme
PA4880 C −6.8 −17.3 −4.5 −4.4 −6.0 −29.6 −12.9 −12.9 Probable bacterioferritin
PA5097 D −4.2 −18.2 −12.5 −5.8 −9.5 −5.2 −3.4 −4.8 Probable amino acid permease
PA5099 C −188.0 −353.2 −54.1 −450.6 −16.2 −14.7 −40.5 −39.9 Probable transporter
PA5212 C −3.1 −5.6 −1.7 −2.5 −8.8 −8.7 −12.1 −5.7 Hypothetical protein
PA5220 B −2.1 −5.5 −1.7 −2.3 −7.7 −8.9 −4.2 −6.9 Hypothetical protein
PA5235 glpT B −4.3 −2.7 −2.6 −5.0 −15.2 −32.4 −2.8 −13.9 Glycerol-3-phosphate transporter
PA5297 poxB D −3.1 −9.4 −2.0 −3.5 −17.8 −6.0 −3.8 −2.8 Pyruvate dehydrogenase (cytochrome)
PA5480 B −10.6 −2.6 1.0 −4.2 −14.2 −19.9 −2.5 −6.1 Hypothetical protein
PA5481 + C −9.6 −30.8 −7.3 −15.0 −45.6 −50.7 −96.6 −22.6 Hypothetical protein
PA5482 + C −5.1 −15.2 −3.5 −9.2 −59.6 −43.0 −81.1 −12.2 Hypothetical protein
a

The effects of sub-MICs of AZM, CFT and CPR on genes belonging to the QS regulon, which is defined elsewhere (74). This regulon consists of genes downregulated in both a ΔlasI-ΔrhlI mutant and a ΔlasR-ΔrhlR mutant of P. aeruginosa PAO1. Genes downregulated more than five times are in boldface, and genes upregulated more than five times are underlined.

b

pprB genes upregulated more than five times (+) or downregulated five times (−) in a ΔpprB mutant of PAO1, as described elsewhere (25).

c

Genes previously reported to be upregulated (+) or downregulated (−) by AZM, as described elsewhere (60).

d

Genes were assigned to one of the following four QS regulation (Reg.) groups: group A, Las-dependent genes, group B, Rhl-dependent genes; group C, genes requiring both a functional Las system and a functional Rhl system; group D, Las-Rhl-regulated genes. See the text for further explanations.