FIG. 4.

Effect of WR301801 on P. falciparum FVO in Aotus. (A) Five Aotus monkeys previously administered a failed regimen of an experimental quinoline methanol were given WR301801 at doses of 8, 16, or 32 mg/kg/day orally for 3 days as indicated by the black bar. Two days after the third dose the animals were rescued with a single 20-mg/kg dose of mefloquine, since the WR301801 treatments failed. However, WR301801 did exhibit a dose-related effect on parasitemia. (B) This is evident when parasitemias are averaged for each dose group and normalized relative to the starting values.