TABLE 5.
Partner drug | ΣFIC (n, range)a
|
|||
---|---|---|---|---|
W2
|
D6
|
|||
Avg for all dilutions | Maximum avg | Avg for all dilutions | Maximum avg | |
Mefloquine | 1.7 (3, 1.3-2.5) | 2.1 (3, 1.5-3.2) | 1.8 (3, 1.3-2.1) | 2.2 (3, 1.7-2.5) |
Chloroquine | 1.5 (2, 1.2-1.7) | 1.9 (2, 1.7-2.1) | 1.5 (2, 1.5-1.5) | 2.2 (2, 2.2-2.2) |
Azithromycin | 1.2 (3, 1.0-1.3) | 1.5 (3, 1.2-1.7) | 1.3 (3, 1.2-1.4) | 1.7 (3, 1.5-1.9) |
Artemisinin | 1.7 (3, 1.7-1.8) | 2.1 (3, 2.0-2.1) | 1.8 (3, 1.7-2.0) | 2.1 (3, 1.9-2.3) |
FICs of <0.5, 1, and >2 are normally considered to be synergistic, additive, and synergistic, respectively. n, number of experiments.