TABLE 1.
Distribution of drug resistance and various genetic characteristics of each sublineage
| Beijing sublineagea | Allele in indicated SNP position of H37Rv:
|
No. (%) of isolates of indicated strain:
|
IS6110 insertion in the NTF region | Point mutations in indicated putative repair genee:
|
Presence or absence of indicated large sequence polymorphismf:
|
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 797736 | 909166 | 1477596 | 1548149 | 1692069 | 1892017 | 2376135 | 2532616 | 2825581 | 4137829 | DS-TB | MDR-TB | XDR-TB | mutT2 | mutT4 | ogt (codon 37) | RD181 | RD150 | RD142 | ||
| ST11 | C | C | C | G | A | T | A | G | T | C | 1 (0.5) | 0 (0) | 0 (0) | None | WT | WT | WT | + | + | + |
| ST26 | C | T | C | G | A | T | A | G | T | C | 10 (5.3) | 21 (21.9) | 17 (36.2) | None | WT | WT | WT | + | + | + |
| Noneb | T | T | C | G | A | T | A | G | G | C | 30 (16.0) | 8 (8.2) | 2 (4.3) | None | WT | WT | WT | - | + | + |
| ST3 | T | C | C | G | A | T | A | G | G | C | 44 (23.4) | 34 (35.1) | 20 (42.6) | None | WT | WT | WT | - | + | + |
| ST25 | T | C | C | G | A | C | A | G | G | T | 3 (1.6) | 1 (1.0) | 0 (0) | None | WT | MT | MT | - | + | + |
| ST19 | T | T | C | G | A | C | A | G | G | T | 63 (33.5) | 14 (14.4) | 3 (6.4) | None | WT | MT | MTc | - | + | + |
| ST10 | T | T | T | G | A | C | A | G | G | T | 29 (15.4) | 8 (8.2) | 1 (2.1) | NTF::IS6110 | MT | MT | WT | - | +d | + |
| ST22 | T | T | T | G | A | C | G | A | G | T | 9 (4.8) | 10 (10.3) | 4 (8.5) | NTF::IS6110 | MT | MT | WT | - | + | + |
a
ST designations from reference 5.
b
New ST, STK, assigned in this study.
c
Nine DS-TB strains and one MDR-TB strain possessed the wild type.
d
Two strains exhibiting ST10 had the RD150 deletion.
e
WT, wild type; MT, mutation.
f
+, presence of large sequence polymorphism; −, absence of large sequence polymorphism.