TABLE 2.
Epidemiological, clinical, and genotypic data from DS-TB, MDR-TB, and XDR-TB isolates
| Drug sensitivity groupa and Beijing sublineage | Epidemiological/clinical information
|
Genotypic information as determined by VNTR analysis
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Total no. (%) of patients | P valueb | No. (%) male | Avg age (yrs) | No. (%) of new cases | Total no. (%) of genotypes by VNTR analysis | P valuec | No. of clusters | No. (%) of cases in cluster | |
| DS | |||||||||
| ST11 | 1 (0.5) | 1 (100) | 54 | 1 (100) | 1 (0.8) | 0 | 0 (0) | ||
| ST26 | 10 (5.3) | 6 (60.0) | 56.6 | 8 (80.0) | 9 (7.3) | 1 | 2 (22.2) | ||
| STK | 30 (15.9) | 22 (73.3) | 58.8 | 23 (76.7) | 27 (22.0) | 3 | 6 (20.0) | ||
| ST3 | 44 (23.3) | 33 (75.0) | 57.2 | 37 (84.1) | 26 (21.1) | 10 | 28 (63.6) | ||
| ST25 | 3 (1.6) | 3 (100) | 61.3 | 2 (66.7) | 2 (1.6) | 1 | 2 (66.7) | ||
| ST19 | 63 (33.3) | 48 (76.2) | 59.3 | 52 (82.5) | 31 (25.2) | 6 | 38 (60.3) | ||
| ST10 | 29 (15.3) | 23 (79.3) | 58.2 | 22 (75.9) | 21 (17.1) | 4 | 12 (41.4) | ||
| ST22 | 9 (4.8) | 5 (55.6) | 54.2 | 9 (100) | 6 (4.9) | 1 | 4 (44.4) | ||
| MDR | |||||||||
| ST11 | 0 (0) | ||||||||
| ST26 | 21 (21.9) | <0.01 | 18 (85.7) | 53.8 | 4 (19.0) | 10 (18.2) | 0.028 | 3 | 14 (63.6) |
| STK | 8 (8.3) | 0.056 | 6 (75.0) | 59.1 | 2 (25.0) | 8 (14.6) | 0.173 | 0 | 0 (0) |
| ST3 | 34 (35.4) | 0.021 | 24 (70.6) | 58.8 | 5 (14.7) | 18 (32.8) | 0.071 | 6 | 22 (64.7) |
| ST25 | 1 (1.0) | 0.563 | 1 (100) | 50 | 1 (100) | 1 (1.8) | 0.705 | 0 | 0 (0) |
| ST19 | 14 (14.6) | <0.01 | 10 (71.4) | 54.9 | 4 (28.6) | 8 (14.6) | 0.082 | 2 | 8 (57.1) |
| ST10 | 8 (8.3) | 0.07 | 5 (62.5) | 44.8 | 5 (62.5) | 6 (10.9) | 0.203 | 2 | 4 (50) |
| ST22 | 10 (10.4) | 0.059 | 9 (90) | 55.8 | 2 (20.0) | 4 (7.3) | 0.387 | 3 | 9 (90) |
| XDR | |||||||||
| ST11 | 0 (0) | ||||||||
| ST26 | 17 (36.2) | <0.01 | 14 (82.4) | 52.4 | 3 (17.6) | 7 (29.2) | <0.01 | 2 | 12 (70.6) |
| STK | 2 (4.3) | 0.033 | 2 (100) | 68 | 0 (0) | 2 (8.3) | 0.105 | 0 | 0 |
| ST3 | 20 (42.6) | <0.01 | 13 (65.0) | 58.2 | 3 (15.0) | 10 (41.7) | 0.03 | 3 | 13 (65.0) |
| ST25 | 0 (0) | ||||||||
| ST19 | 3 (6.4) | <0.01 | 2 (66.7) | 59.3 | 2 (66.7) | 2 (8.3) | 0.061 | 1 | 2 (66.7) |
| ST10 | 1 (2.1) | 0.014 | 1 (100) | 52 | 0 (0) | 1 (4.2) | 0.095 | 0 | 0 (0) |
| ST22 | 4 (8.5) | 0.257 | 3 (75.0) | 46.5 | 1 (25.0) | 2 (8.3) | 0.425 | 1 | 3 (75.0) |
a
There were 189 DS-TB, 96 MDR-TB, and 47 XDR-TB isolates.
b
P value of Z test for proportion between DS versus MDR and DS versus XDR patients.
c
P value of Z test for proportion between DS versus MDR and DS versus XDR genotypes.