FIG. 3.
Relationship between micafungin total (left) and free (right) drug 24-h AUC/MIC and efficacy against four C. albicans strains. Each symbol represents the mean CFU/kidneys from three mice. Efficacy on the y axis is expressed as the change in CFU/kidneys compared to the burden of organisms compared to the start of therapy. The dashed horizontal line represents the burden of organisms in thighs at the start of therapy. The sigmoid line represents the best-fit curve using the sigmoid Emax model. The R2 is the coefficient of determination.