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Caspofungin, anidulafungin, and micafungin MICs in the presence and absence of 50% human serum
| C. glabrata isolate | MIC (μg/ml) with no human serum/50% human seruma
|
|||||
|---|---|---|---|---|---|---|
| Caspofungin
|
Anidulafungin
|
Micafungin
|
||||
| 24 h | 48 h | 24 h | 48 h | 24 h | 48 h | |
| 7754 | 0.25/0.5 | 0.25/0.5 | 0.125/1 | 0.125/2 | 0.125/1 | 0.125/4 |
| 7755 | 2/2 | 8/8 | 0.5/4 | 1/4 | 0.25/4 | 0.5/4 |
MICs were read at 24 and 48 h as the lowest concentration of drug resulting in a significant (≥50%) decrease in turbidity compared to the growth control.
