TABLE 3.
Functional Tat signal sequences in M. tuberculosis proteins identified with the ′BlaC reporter
| Protein | Description | No. of times identified in libraries | In silico prediction
|
||
|---|---|---|---|---|---|
| TatP | TATFIND | TigrFAM | |||
| Rv0063 | Possible oxidoreductase | 1 | No | No | Yes |
| Rv0315 | Possible beta-1,3-glucanase precursor | 41 | Yes | Yes | Yes |
| Rv0483 (LprQ) | Possible conserved lipoprotein | 2 | No | No | No |
| Rv0519c | Possible lipase | 5 | Yes | No | Yes |
| Rv0774c | Possible lipase; short-chain alcohol dehydrogenase family | 12 | Yes | Yes | Yes |
| Rv0846c | Possible multicopper oxidase | 1 | Yes | Yes | Yes |
| Rv2068c (BlaC) | Class A β-lactamase | 63 | Yes | Yes | Yes |
| Rv2350c (PlcB) | Phospholipase C | 1 | Yes | Yes | Yes |
| Rv2833c (UgpB) | Possible glycerol-3-phosphate-binding lipoprotein | 3 | Yes | Yes | Yes |
| Rv2843 | Possible conserved transmembrane Ala-rich protein | 1 | No | Yes | Yes |
| Rv2041c | Possible sugar-binding lipoprotein | 0a | Yes | Yes | Yes |
| Rv2351c (PlcA) | Phospholipase C | 0a | Yes | No | Yes |
| Rv2525c | Conserved hypothetical protein | 0a | Yes | Yes | Yes |
a
Demonstrated by direct testing only.