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Amino acid alignment showing substitutions in the transpeptidase region of PBP2 for 25 N. meningitidis isolates from South Africa, 2001 to 2005, with intermediate resistance to penicillin. Dashes indicate residues identical to those in the sequence of the Pens strain. The conserved KTG motif in the Pens strain is underlined. Boldfaced residues are common to all 25 isolates. An asterisk marks the position where some isolates have an Asn insertion.
